Pathogenesis of rhinitis

Decreased serum level of lipoxin A4 (LXA4) may contribute to the pathogenesis of allergic rhinitis

Background: Rhinitis is a prevalent chronic inflammatory disease of the nasal mucosa. Arachidonic acid-derived lipoxin A4 (LXA4) has long been recognized to exert crucial anti-inflammatory and pro-resolving effects on inflammatory responses through a specific receptor named formyl peptide receptor-2 (FPR2). This study aimed to determine the serum level of LXA4 as well as the relative mRNA expre...

New insights into the pathogenesis of non-allergic rhinitis

Background Effective treatment requires a correct diagnosis, however for different subgroups of chronic rhinitis patients differentiation on a clinical level is complicated. In the case of non-allergic rhinitis (NAR) that represents a wide spectrum of diseases, we are also faced with a missing mechanistic or molecular diagnosis. Here we present an unbiased transcriptomic approach on nasal epith...

Pathogenesis of Epilepsy: Challenges in Animal Models

  Epilepsy is one of the most common chronic disorders affecting individuals of all ages. A greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. Therefore, severa...

The Immunological Basis in the Pathogenesis of Gout

ACUPUNCTURE AND ALLERGIC RHINITIS About allergic rhinitis

The condition can affect several organ systems, and cause many symptoms. Typical symptoms include sneezing, nasal itching, nasal blockage, and watery nasal discharge.(Lund 1994) Other symptoms include eye symptoms (e.g. red eyes, itchy eyes, tearing), coughing, wheezing and shortness of breath, oral allergy syndrome (i.e. an itchy, swollen oropharynx on eating stoned fruits), and systemic sympt...